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https://staging-thebottomlineh.kinsta.cloud A compendium of critical appraisals in Intensive Care Medicine research and related specialties Fri, 10 Dec 2021 10:36:49 +0000 en-GB hourly 1 https://wordpress.org/?v=5.8.14 https://staging-thebottomlineh.kinsta.cloud/wp-content/uploads/2016/05/cropped-tbl-favicon-2-32x32.png https://staging-thebottomlineh.kinsta.cloud 32 32 https://staging-thebottomlineh.kinsta.cloud/summaries/combat-covid/?utm_source=rss&utm_medium=rss&utm_campaign=combat-covid https://staging-thebottomlineh.kinsta.cloud/summaries/combat-covid/#respond Fri, 10 Dec 2021 10:36:49 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10166 In mechanically ventilated patients with COVID-19 and severe endotheliopathy, does prostacylin compared with placebo, improve days alive without ventilation by day 28?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/combat-covid/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/coca/?utm_source=rss&utm_medium=rss&utm_campaign=coca https://staging-thebottomlineh.kinsta.cloud/summaries/coca/#respond Fri, 03 Dec 2021 16:20:28 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10160 In patients with out-of-hospital cardiac arrest, does calcium compared with placebo, improve sustained return of spontaneous circulation?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/coca/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/silence/?utm_source=rss&utm_medium=rss&utm_campaign=silence https://staging-thebottomlineh.kinsta.cloud/summaries/silence/#respond Wed, 17 Nov 2021 10:45:28 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9874 In patients near end of life, does subcutaneous scopolamine butylbromide compared with placebo, reduce the incidence of death rattle?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/silence/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/recovery-regen-cov/?utm_source=rss&utm_medium=rss&utm_campaign=recovery-regen-cov https://staging-thebottomlineh.kinsta.cloud/summaries/recovery-regen-cov/#respond Thu, 30 Sep 2021 21:29:01 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9857 Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial @PeterHorby. medRxiv pre-print 2021 doi: https://doi.org/10.1101/2021.06.15.21258542 Clinical Question In hospitalised patients with COVID-19, does the addition of monoclonal antibodies REGEN-COV (carsirivimab & imdevimab) to standard care, compared with standard care alone, improve 28 day mortality? Background Monoclonal antibodies have been shown to be […]]]> https://staging-thebottomlineh.kinsta.cloud/summaries/recovery-regen-cov/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/covid-steroid-2/?utm_source=rss&utm_medium=rss&utm_campaign=covid-steroid-2 https://staging-thebottomlineh.kinsta.cloud/summaries/covid-steroid-2/#respond Thu, 09 Sep 2021 09:38:49 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9836 In patients with severe COVID, does 12mg dexamethasone vs 6mg dexamethasone increase the number of days alive without life support at 28 days?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/covid-steroid-2/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/treatment-of-multisystem-inflammatory-syndrome-in-children/?utm_source=rss&utm_medium=rss&utm_campaign=treatment-of-multisystem-inflammatory-syndrome-in-children https://staging-thebottomlineh.kinsta.cloud/summaries/treatment-of-multisystem-inflammatory-syndrome-in-children/#respond Fri, 30 Jul 2021 12:24:43 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9617 Treatment of Multisystem Inflammatory Syndrome in Children McArdle. NEJM 2021; 385: 35-45.DOI: 10.1056/NEJMoa2102968 Clinical Question In children with multisystem inflammatory syndrome, what affect do different treatments have on the composite of inotropic support or mechanical ventilation by day 2 or death, and disease severity by day 2? Background Multisystem inflammatory syndrome in children (MIS-C) is a new, rare but serious […]]]> https://staging-thebottomlineh.kinsta.cloud/summaries/treatment-of-multisystem-inflammatory-syndrome-in-children/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/dexa-ards/?utm_source=rss&utm_medium=rss&utm_campaign=dexa-ards https://staging-thebottomlineh.kinsta.cloud/summaries/dexa-ards/#respond Wed, 21 Apr 2021 12:27:37 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=9400 In patients with moderate-severe ARDS, does dexamethasone in addition to routine care, compared with routine care alone increase ventilator free days up to day 28?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/dexa-ards/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/remap-cap-il-6/?utm_source=rss&utm_medium=rss&utm_campaign=remap-cap-il-6 https://staging-thebottomlineh.kinsta.cloud/summaries/remap-cap-il-6/#respond Mon, 11 Jan 2021 17:34:31 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=9211 In critically ill patients with COVID-19, do the IL-6 receptor antagonists, tocilizumab and sarilumab, compared with standard care, improve respiratory and cardiovascular organ support free days up to day 21?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/remap-cap-il-6/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/grecco-19/?utm_source=rss&utm_medium=rss&utm_campaign=grecco-19 https://staging-thebottomlineh.kinsta.cloud/summaries/grecco-19/#respond Fri, 31 Jul 2020 14:43:51 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=8712 In patients hospitalised with symptomatic coronavirus disease 2019, does the administration of colchicine improve clinical & laboratory outcomes?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/grecco-19/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/peptic/?utm_source=rss&utm_medium=rss&utm_campaign=peptic https://staging-thebottomlineh.kinsta.cloud/summaries/peptic/#respond Fri, 31 Jan 2020 08:05:15 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=8231 In ICU patients requiring invasive mechanical ventilation, does the use of proton pump inhibitors (PPIs) vs. histamine-2 receptor blockers (H2RBs) for stress-ulcer prophylaxis, reduce 90-day mortality?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/peptic/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/esett/?utm_source=rss&utm_medium=rss&utm_campaign=esett https://staging-thebottomlineh.kinsta.cloud/summaries/icm/esett/#respond Fri, 17 Jan 2020 11:17:40 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=8060 In patients with status epilepticus who have been treated with benzodiazepines, is Levetriracetam, Valproate or Fosphenyoin more likely to lead to an absence of seizures and improved responsiveness at 60 minutes?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/esett/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/colcot/?utm_source=rss&utm_medium=rss&utm_campaign=colcot https://staging-thebottomlineh.kinsta.cloud/summaries/icm/colcot/#respond Fri, 22 Nov 2019 19:58:28 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=7849 In patients post myocardial infarction, does low dose colchicine compared with placebo, reduce ischaemic cardiovascular events?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/colcot/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/garrouste-orgeas/?utm_source=rss&utm_medium=rss&utm_campaign=garrouste-orgeas https://staging-thebottomlineh.kinsta.cloud/summaries/icm/garrouste-orgeas/#respond Fri, 04 Oct 2019 15:44:28 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=7814 In intensive care patients, does an ICU diary compared to no ICU diary, reduce post-traumatic stress disorder symptoms at 3 months?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/garrouste-orgeas/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/avert-shock/?utm_source=rss&utm_medium=rss&utm_campaign=avert-shock https://staging-thebottomlineh.kinsta.cloud/summaries/avert-shock/#comments Fri, 06 Sep 2019 16:25:35 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=7851 In trauma patients with hemorrhagic shock, does the use of low-dose arginine vasopressin compared to placebo reduce the volume of blood products transfused?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/avert-shock/feed/ 1 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/probese/?utm_source=rss&utm_medium=rss&utm_campaign=probese https://staging-thebottomlineh.kinsta.cloud/summaries/icm/probese/#respond Fri, 02 Aug 2019 11:00:16 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=7731 In obese patients, does the use of recruitment maneuvers with high PEEP, compared with low PEEP, decrease postoperative pulmonary complications?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/probese/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/optalyse-pe/?utm_source=rss&utm_medium=rss&utm_campaign=optalyse-pe https://staging-thebottomlineh.kinsta.cloud/summaries/optalyse-pe/#respond Fri, 05 Jul 2019 20:37:15 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=7663 In patients with intermediate risk PE, do low doses of tPA and short durations of ultrasound facilitated catheter directed thrombolysis, result in a reduction in RV:LV diameter at 48 hours?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/optalyse-pe/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/extend/?utm_source=rss&utm_medium=rss&utm_campaign=extend https://staging-thebottomlineh.kinsta.cloud/summaries/extend/#respond Fri, 31 May 2019 15:21:07 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=7370 In patients with acute ischaemic stroke, with salvageable brain tissue, does alteplase compared with placebo, administered between 4.5 - 9 hours post stroke onset, improve functional outcome at 90 days?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/extend/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/evald/?utm_source=rss&utm_medium=rss&utm_campaign=evald https://staging-thebottomlineh.kinsta.cloud/summaries/icm/evald/#respond Fri, 19 Apr 2019 12:47:42 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=7372 In patients that survive with a good neurological outcome following out-of-hospital cardiac arrest, does 48 hours vs. 24 hours of therapeutic hypothermia, improve memory, attention & executive function at 6 months?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/evald/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/hercules/?utm_source=rss&utm_medium=rss&utm_campaign=hercules https://staging-thebottomlineh.kinsta.cloud/summaries/hercules/#respond Fri, 25 Jan 2019 15:51:37 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=6826 In patients with acquired thrombocytopenia purport, does calpacizumab compared with placebo, reduce the time to normalisation of the platelet count?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/hercules/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/ideal-icu/?utm_source=rss&utm_medium=rss&utm_campaign=ideal-icu https://staging-thebottomlineh.kinsta.cloud/summaries/icm/ideal-icu/#respond Fri, 09 Nov 2018 14:46:56 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=6132 patients with septic shock and severe acute kidney injury, does early vs. delayed renal replacement therapy improve 90 day mortality?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/ideal-icu/feed/ 0