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https://staging-thebottomlineh.kinsta.cloud A compendium of critical appraisals in Intensive Care Medicine research and related specialties Tue, 04 Jan 2022 14:10:36 +0000 en-GB hourly 1 https://wordpress.org/?v=5.8.14 https://staging-thebottomlineh.kinsta.cloud/wp-content/uploads/2016/05/cropped-tbl-favicon-2-32x32.png https://staging-thebottomlineh.kinsta.cloud 32 32 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-december-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-december-2021 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-december-2021/#respond Tue, 04 Jan 2022 14:10:36 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10239 What’s new in the Critical Care literature – monthly updates]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-december-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-november-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-november-2021 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-november-2021/#respond Thu, 16 Dec 2021 10:54:55 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10215 What’s new in the Critical Care literature – monthly updates]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-november-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-october-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-october-2021 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-october-2021/#respond Thu, 18 Nov 2021 13:31:28 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10157 What’s new in the Critical Care literature – monthly updates ]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-october-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-september-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-september-2021 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-september-2021/#respond Wed, 06 Oct 2021 08:51:12 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10080 What’s new in the Critical Care literature – monthly updates]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-september-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-august-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-august-2021 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-august-2021/#respond Sat, 04 Sep 2021 16:29:00 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9923 What's new in the Critical Care literature - monthly updates ]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-august-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-care-evidence-updates-july-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-july-2021 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-care-evidence-updates-july-2021/#respond Mon, 02 Aug 2021 12:40:00 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9743 What’s new in the Critical Care literature – monthly updates ]]> https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-care-evidence-updates-july-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-june-21/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-june-21 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-june-21/#respond Wed, 21 Jul 2021 08:36:43 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9698 What's new in the Critical Care literature - monthly updates ]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-june-21/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/vitamins/?utm_source=rss&utm_medium=rss&utm_campaign=vitamins https://staging-thebottomlineh.kinsta.cloud/summaries/icm/vitamins/#comments Sun, 19 Jan 2020 11:05:39 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=8148 Does treatment with vitamin C, hydrocortisone, and thiamine lead to a more rapid resolution of septic shock compared with hydrocortisone alone?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/vitamins/feed/ 2 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/the-rapid-administration-of-carnitine-in-sepsis-race-randomized-clinical-trial/?utm_source=rss&utm_medium=rss&utm_campaign=the-rapid-administration-of-carnitine-in-sepsis-race-randomized-clinical-trial https://staging-thebottomlineh.kinsta.cloud/summaries/icm/the-rapid-administration-of-carnitine-in-sepsis-race-randomized-clinical-trial/#respond Fri, 18 Jan 2019 17:44:28 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=6803 Do one or more doses of levocarnitine reduce organ failure in septic shock at 48 hours, compared with placebo? ]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/the-rapid-administration-of-carnitine-in-sepsis-race-randomized-clinical-trial/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/trics3-long-term/?utm_source=rss&utm_medium=rss&utm_campaign=trics3-long-term https://staging-thebottomlineh.kinsta.cloud/summaries/icm/trics3-long-term/#respond Fri, 05 Oct 2018 15:35:43 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=6469 In patients undergoing cardiac surgery, who have a moderate-to-high risk of death, does a restrictive transfusion strategy compared with a liberal strategy impact on a composite outcome of death, myocardial infarction, stroke and acute kidney injury requiring dialysis at 6 months after surgery?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/trics3-long-term/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/airways-2/?utm_source=rss&utm_medium=rss&utm_campaign=airways-2 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/airways-2/#respond Fri, 07 Sep 2018 14:11:50 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=6340 In adult patients with non-traumatic out-of-hospital cardiac arrest, does a supraglottic airway device compared with tracheal intubation as the initial advanced airway management strategy, improve functional neurological outcome?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/airways-2/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/bicar-icu/?utm_source=rss&utm_medium=rss&utm_campaign=bicar-icu https://staging-thebottomlineh.kinsta.cloud/summaries/icm/bicar-icu/#comments Fri, 22 Jun 2018 06:37:46 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=6085 In critically ill patients with severe metabolic acidaemia (pH ≤7⋅20), does the infusion of sodium bicarbonate, compared with no infusion, to reach and maintain a targeted pH of 7⋅30 decrease the primary composite out­come of mortality by day 28 or the presence of at least one organ failure at day 7?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/bicar-icu/feed/ 5 https://staging-thebottomlineh.kinsta.cloud/summaries/relief/?utm_source=rss&utm_medium=rss&utm_campaign=relief https://staging-thebottomlineh.kinsta.cloud/summaries/relief/#comments Fri, 18 May 2018 00:00:47 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=5934 In adult patients undergoing major elective abdominal surgery, does a restrictive fluid regimen compared with a liberal fluid regimen reduce complications and improved disability-free survival?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/relief/feed/ 5 https://staging-thebottomlineh.kinsta.cloud/blog/steroids-in-sepsis/?utm_source=rss&utm_medium=rss&utm_campaign=steroids-in-sepsis https://staging-thebottomlineh.kinsta.cloud/blog/steroids-in-sepsis/#comments Fri, 05 Jan 2018 12:00:43 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=5194 In patients with septic shock, do corticosteroids compared to placebo reduce mortality? This is an editorial blog post in anticipation of the ADRENAL trial results to be presented at #CCR18.]]> https://staging-thebottomlineh.kinsta.cloud/blog/steroids-in-sepsis/feed/ 4 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/epicc/?utm_source=rss&utm_medium=rss&utm_campaign=epicc https://staging-thebottomlineh.kinsta.cloud/summaries/icm/epicc/#respond Fri, 18 Aug 2017 18:22:06 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=4499 Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial Wright. 2017. Thorax 2017: 0:1–9. doi:10.1136/thoraxjnl-2016-209858 Clinical Question Does an increased intensity of ICU based physical rehabilitation therapy improve improve long-term physical quality of life compared with a standard intensity of physical rehabilitation? Background Physical and psychological recovery after a period of critical […]]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/epicc/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/p-value/?utm_source=rss&utm_medium=rss&utm_campaign=p-value https://staging-thebottomlineh.kinsta.cloud/blog/ebm/p-value/#comments Sun, 30 Jul 2017 11:29:30 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=3514 P-values - interpreting the evidence series]]> https://staging-thebottomlineh.kinsta.cloud/blog/ebm/p-value/feed/ 1 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/condolence/?utm_source=rss&utm_medium=rss&utm_campaign=condolence https://staging-thebottomlineh.kinsta.cloud/summaries/icm/condolence/#comments Fri, 07 Jul 2017 13:16:06 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=3266 Among relatives who died in the Intensive Care Unit (ICU), does a condolence letter from a clinician, compared to no condolence letter, effect grief symptoms?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/condolence/feed/ 1 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/detsky/?utm_source=rss&utm_medium=rss&utm_campaign=detsky https://staging-thebottomlineh.kinsta.cloud/summaries/icm/detsky/#respond Fri, 16 Jun 2017 12:00:44 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=4128 What is the discriminative accuracy of physicians and nurses in predicting 6-month mortality and functional outcomes of critically ill patients?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/detsky/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-appraisal-glossary/?utm_source=rss&utm_medium=rss&utm_campaign=critical-appraisal-glossary https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-appraisal-glossary/#respond Sat, 27 May 2017 17:06:34 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=3680 Rather than reinvent the wheel, we are delighted to include a link to the RCEM Critical Appraisal Dictionary. The RCEM learning site provides excellent open access educational resources, including critical care appraisal modules]]> https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-appraisal-glossary/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/type-1-and-2-errors/?utm_source=rss&utm_medium=rss&utm_campaign=type-1-and-2-errors https://staging-thebottomlineh.kinsta.cloud/blog/ebm/type-1-and-2-errors/#respond Fri, 19 May 2017 19:55:49 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=3759 In statistical hypothesis testing, a type I error is the incorrect rejection of a true null hypothesis (a "false positive"), while a type II error is incorrectly retaining a false null hypothesis (a "false negative"). The more you try and avoid a Type I error (false positive), the more likely a Type II error (false negative) may happen. Researchers have found that an alpha level of 5% is a good balance between these two issues]]> https://staging-thebottomlineh.kinsta.cloud/blog/ebm/type-1-and-2-errors/feed/ 0