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https://staging-thebottomlineh.kinsta.cloud A compendium of critical appraisals in Intensive Care Medicine research and related specialties Tue, 04 Jan 2022 14:10:36 +0000 en-GB hourly 1 https://wordpress.org/?v=5.8.14 https://staging-thebottomlineh.kinsta.cloud/wp-content/uploads/2016/05/cropped-tbl-favicon-2-32x32.png https://staging-thebottomlineh.kinsta.cloud 32 32 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-december-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-december-2021 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-december-2021/#respond Tue, 04 Jan 2022 14:10:36 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10239 What’s new in the Critical Care literature – monthly updates]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-december-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-november-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-november-2021 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-november-2021/#respond Thu, 16 Dec 2021 10:54:55 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10215 What’s new in the Critical Care literature – monthly updates]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-november-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-october-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-october-2021 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-october-2021/#respond Thu, 18 Nov 2021 13:31:28 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10157 What’s new in the Critical Care literature – monthly updates ]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-october-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-september-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-september-2021 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-september-2021/#respond Wed, 06 Oct 2021 08:51:12 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10080 What’s new in the Critical Care literature – monthly updates]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-september-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-august-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-august-2021 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-august-2021/#respond Sat, 04 Sep 2021 16:29:00 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9923 What's new in the Critical Care literature - monthly updates ]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-august-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-care-evidence-updates-july-2021/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-july-2021 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-care-evidence-updates-july-2021/#respond Mon, 02 Aug 2021 12:40:00 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9743 What’s new in the Critical Care literature – monthly updates ]]> https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-care-evidence-updates-july-2021/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-june-21/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-evidence-updates-june-21 https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-june-21/#respond Wed, 21 Jul 2021 08:36:43 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9698 What's new in the Critical Care literature - monthly updates ]]> https://staging-thebottomlineh.kinsta.cloud/blog/critical-care-evidence-updates-june-21/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/bayesian-statistics/?utm_source=rss&utm_medium=rss&utm_campaign=bayesian-statistics https://staging-thebottomlineh.kinsta.cloud/blog/ebm/bayesian-statistics/#respond Fri, 11 Sep 2020 15:10:18 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=8894 Bayesian Statistics “Under Bayes’ Theorem, no theory is perfect. Rather it is a work in progress, always subject to refinement and further testing” Nate Silver Introduction With the recent publication of the REMAP-CAP steroid arm and the Bayesian post-hoc re-analysis of the EOLIA trial, it appears Bayesian statistics are appearing more frequently in critical care trials. The purpose of this […]]]> https://staging-thebottomlineh.kinsta.cloud/blog/ebm/bayesian-statistics/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/editorial/tbl-at-wics-summer-2019/?utm_source=rss&utm_medium=rss&utm_campaign=tbl-at-wics-summer-2019 https://staging-thebottomlineh.kinsta.cloud/blog/editorial/tbl-at-wics-summer-2019/#respond Fri, 14 Jun 2019 08:08:57 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=7611 TBL at Wessex Intensive Care Society meeting 2019 #WICS19 It’s a pleasure to be speaking at WICS 2019. I will be producing notes here to support my talk later today. This will include a narrative of my slides, a little more depth of content and links to all the trials. In short, here are my 6 key statements: Video-laryngoscopy is […]]]> https://staging-thebottomlineh.kinsta.cloud/blog/editorial/tbl-at-wics-summer-2019/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/editorial/tbl-at-baoia/?utm_source=rss&utm_medium=rss&utm_campaign=tbl-at-baoia https://staging-thebottomlineh.kinsta.cloud/blog/editorial/tbl-at-baoia/#respond Sat, 06 Oct 2018 09:00:46 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=6484 This editorial blog has been written to complement the short presentation delivered by Duncan Chambler at the British Association of Indian Anaesthetists (BAOIA) 2018 conference in Newcastle.]]> https://staging-thebottomlineh.kinsta.cloud/blog/editorial/tbl-at-baoia/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/editorial/power-and-sample-size/?utm_source=rss&utm_medium=rss&utm_campaign=power-and-sample-size https://staging-thebottomlineh.kinsta.cloud/blog/editorial/power-and-sample-size/#comments Fri, 27 Apr 2018 12:00:16 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=5795 In this Editorial, Professor Imelda Galvin from Queen's University in Canada takes us through the details of Power, how it relates to trial sample size, and why it matters.]]> https://staging-thebottomlineh.kinsta.cloud/blog/editorial/power-and-sample-size/feed/ 2 https://staging-thebottomlineh.kinsta.cloud/blog/steroids-in-sepsis/?utm_source=rss&utm_medium=rss&utm_campaign=steroids-in-sepsis https://staging-thebottomlineh.kinsta.cloud/blog/steroids-in-sepsis/#comments Fri, 05 Jan 2018 12:00:43 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=5194 In patients with septic shock, do corticosteroids compared to placebo reduce mortality? This is an editorial blog post in anticipation of the ADRENAL trial results to be presented at #CCR18.]]> https://staging-thebottomlineh.kinsta.cloud/blog/steroids-in-sepsis/feed/ 4 https://staging-thebottomlineh.kinsta.cloud/blog/editorial/top-10-for-2017/?utm_source=rss&utm_medium=rss&utm_campaign=top-10-for-2017 https://staging-thebottomlineh.kinsta.cloud/blog/editorial/top-10-for-2017/#respond Fri, 22 Dec 2017 12:00:01 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=5187 It's been another big year for research in ICM, EM and Peri-operative Care. What do the TBL editors think are the best trials of 2017?]]> https://staging-thebottomlineh.kinsta.cloud/blog/editorial/top-10-for-2017/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/p-value/?utm_source=rss&utm_medium=rss&utm_campaign=p-value https://staging-thebottomlineh.kinsta.cloud/blog/ebm/p-value/#comments Sun, 30 Jul 2017 11:29:30 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=3514 P-values - interpreting the evidence series]]> https://staging-thebottomlineh.kinsta.cloud/blog/ebm/p-value/feed/ 1 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-appraisal-glossary/?utm_source=rss&utm_medium=rss&utm_campaign=critical-appraisal-glossary https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-appraisal-glossary/#respond Sat, 27 May 2017 17:06:34 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=3680 Rather than reinvent the wheel, we are delighted to include a link to the RCEM Critical Appraisal Dictionary. The RCEM learning site provides excellent open access educational resources, including critical care appraisal modules]]> https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-appraisal-glossary/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/type-1-and-2-errors/?utm_source=rss&utm_medium=rss&utm_campaign=type-1-and-2-errors https://staging-thebottomlineh.kinsta.cloud/blog/ebm/type-1-and-2-errors/#respond Fri, 19 May 2017 19:55:49 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=3759 In statistical hypothesis testing, a type I error is the incorrect rejection of a true null hypothesis (a "false positive"), while a type II error is incorrectly retaining a false null hypothesis (a "false negative"). The more you try and avoid a Type I error (false positive), the more likely a Type II error (false negative) may happen. Researchers have found that an alpha level of 5% is a good balance between these two issues]]> https://staging-thebottomlineh.kinsta.cloud/blog/ebm/type-1-and-2-errors/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/fragility-index/?utm_source=rss&utm_medium=rss&utm_campaign=fragility-index https://staging-thebottomlineh.kinsta.cloud/blog/ebm/fragility-index/#comments Sun, 30 Apr 2017 14:54:33 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=3414 Fragility Index is the minimum number of patients whose status would have to change from a "non-event" (not having the primary endpoint) to an "event" (having the primary end point) in order to turn a statistically significant result to a nonsignificant result. It is a simple metric to calculate and use. Reporting the Fragility Index in RCTs may help readers make more informed decisions about the confidence warranted by RCT results ]]> https://staging-thebottomlineh.kinsta.cloud/blog/ebm/fragility-index/feed/ 4 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-care-symposium-2017/?utm_source=rss&utm_medium=rss&utm_campaign=critical-care-symposium-2017 https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-care-symposium-2017/#respond Thu, 27 Apr 2017 16:30:13 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=3849 Slides and handout from the the 'Critical Care Game Changers' (updates in critical care) presentation at Critical Care Symposium 2017]]> https://staging-thebottomlineh.kinsta.cloud/blog/ebm/critical-care-symposium-2017/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/news/2016-round-up/?utm_source=rss&utm_medium=rss&utm_campaign=2016-round-up https://staging-thebottomlineh.kinsta.cloud/blog/news/2016-round-up/#respond Fri, 23 Dec 2016 12:00:40 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=3015 All of us on the editorial team would like to wish our subscribers, followers and readers our very best wishes for this festive season and the year ahead. We're taking our usual two week break, and we shall return in 2017 with more #FOAMed.]]> https://staging-thebottomlineh.kinsta.cloud/blog/news/2016-round-up/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/blog/editorial/pocus-summary/?utm_source=rss&utm_medium=rss&utm_campaign=pocus-summary https://staging-thebottomlineh.kinsta.cloud/blog/editorial/pocus-summary/#respond Fri, 18 Nov 2016 16:00:22 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=2932 We've covered five key papers from a range of researchers with a focus on Point-of-Care Ultrasound. This has been complemented by the excellent 'Introduction to...' blog posts from Adrian and Segun.]]> https://staging-thebottomlineh.kinsta.cloud/blog/editorial/pocus-summary/feed/ 0