Deprecated: Return type of WP_Theme::offsetExists($offset) should either be compatible with ArrayAccess::offsetExists(mixed $offset): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-theme.php on line 554

Deprecated: Return type of WP_Theme::offsetGet($offset) should either be compatible with ArrayAccess::offsetGet(mixed $offset): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-theme.php on line 595

Deprecated: Return type of WP_Theme::offsetSet($offset, $value) should either be compatible with ArrayAccess::offsetSet(mixed $offset, mixed $value): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-theme.php on line 535

Deprecated: Return type of WP_Theme::offsetUnset($offset) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-theme.php on line 544

Deprecated: Return type of WP_REST_Request::offsetExists($offset) should either be compatible with ArrayAccess::offsetExists(mixed $offset): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/rest-api/class-wp-rest-request.php on line 960

Deprecated: Return type of WP_REST_Request::offsetGet($offset) should either be compatible with ArrayAccess::offsetGet(mixed $offset): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/rest-api/class-wp-rest-request.php on line 980

Deprecated: Return type of WP_REST_Request::offsetSet($offset, $value) should either be compatible with ArrayAccess::offsetSet(mixed $offset, mixed $value): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/rest-api/class-wp-rest-request.php on line 992

Deprecated: Return type of WP_REST_Request::offsetUnset($offset) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/rest-api/class-wp-rest-request.php on line 1003

Deprecated: Return type of WP_Block_List::current() should either be compatible with Iterator::current(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-block-list.php on line 151

Deprecated: Return type of WP_Block_List::next() should either be compatible with Iterator::next(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-block-list.php on line 175

Deprecated: Return type of WP_Block_List::key() should either be compatible with Iterator::key(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-block-list.php on line 164

Deprecated: Return type of WP_Block_List::valid() should either be compatible with Iterator::valid(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-block-list.php on line 186

Deprecated: Return type of WP_Block_List::rewind() should either be compatible with Iterator::rewind(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-block-list.php on line 138

Deprecated: Return type of WP_Block_List::offsetExists($index) should either be compatible with ArrayAccess::offsetExists(mixed $offset): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-block-list.php on line 75

Deprecated: Return type of WP_Block_List::offsetGet($index) should either be compatible with ArrayAccess::offsetGet(mixed $offset): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-block-list.php on line 89

Deprecated: Return type of WP_Block_List::offsetSet($index, $value) should either be compatible with ArrayAccess::offsetSet(mixed $offset, mixed $value): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-block-list.php on line 110

Deprecated: Return type of WP_Block_List::offsetUnset($index) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-block-list.php on line 127

Deprecated: Return type of WP_Block_List::count() should either be compatible with Countable::count(): int, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-includes/class-wp-block-list.php on line 199

Warning: Private methods cannot be final as they are never overridden by other classes in /www/thebottomlineh_300/public/wp-content/plugins/post-state-tags/post-state-tags.php on line 77

Deprecated: load_plugin_textdomain was called with an argument that is deprecated since version 2.7.0 with no alternative available. in /www/thebottomlineh_300/public/wp-includes/functions.php on line 5507

Deprecated: Optional parameter $setting declared before required parameter $value is implicitly treated as a required parameter in /www/thebottomlineh_300/public/wp-content/plugins/simple-post-template/vendor/objectivco/wordpress-simple-settings/src/wordpress-simple-settings.php on line 46

Deprecated: Optional parameter $setting declared before required parameter $value is implicitly treated as a required parameter in /www/thebottomlineh_300/public/wp-content/plugins/simple-post-template/vendor/objectivco/wordpress-simple-settings/src/wordpress-simple-settings.php on line 64

Deprecated: Return type of tad_DI52_Container::offsetExists($offset) should either be compatible with ArrayAccess::offsetExists(mixed $offset): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/tribe-common/vendor/lucatume/di52/src/tad/DI52/Container.php on line 549

Deprecated: Return type of tad_DI52_Container::offsetGet($offset) should either be compatible with ArrayAccess::offsetGet(mixed $offset): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/tribe-common/vendor/lucatume/di52/src/tad/DI52/Container.php on line 218

Deprecated: Return type of tad_DI52_Container::offsetSet($offset, $value) should either be compatible with ArrayAccess::offsetSet(mixed $offset, mixed $value): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/tribe-common/vendor/lucatume/di52/src/tad/DI52/Container.php on line 163

Deprecated: Return type of tad_DI52_Container::offsetUnset($offset) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/tribe-common/vendor/lucatume/di52/src/tad/DI52/Container.php on line 603

Deprecated: Return type of MC4WP_Container::offsetExists($offset) should either be compatible with ArrayAccess::offsetExists(mixed $offset): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/mailchimp-for-wp/includes/class-container.php on line 71

Deprecated: Return type of MC4WP_Container::offsetGet($offset) should either be compatible with ArrayAccess::offsetGet(mixed $offset): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/mailchimp-for-wp/includes/class-container.php on line 86

Deprecated: Return type of MC4WP_Container::offsetSet($offset, $value) should either be compatible with ArrayAccess::offsetSet(mixed $offset, mixed $value): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/mailchimp-for-wp/includes/class-container.php on line 104

Deprecated: Return type of MC4WP_Container::offsetUnset($offset) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/mailchimp-for-wp/includes/class-container.php on line 119

Deprecated: Optional parameter $post_id declared before required parameter $meta_key is implicitly treated as a required parameter in /www/thebottomlineh_300/public/wp-content/plugins/tlp-team/lib/classes/TLPTeamHelper.php on line 436

Deprecated: Optional parameter $items declared before required parameter $fields is implicitly treated as a required parameter in /www/thebottomlineh_300/public/wp-content/plugins/tlp-team/lib/classes/TLPTeamHelper.php on line 620

Deprecated: Optional parameter $empty declared before required parameter $term_id is implicitly treated as a required parameter in /www/thebottomlineh_300/public/wp-content/plugins/tlp-team/lib/classes/TLPTeamItemSorting.php on line 67

Deprecated: Return type of Pods\Whatsit::offsetExists($offset) should either be compatible with ArrayAccess::offsetExists(mixed $offset): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/src/Pods/Whatsit.php on line 351

Deprecated: Return type of & Pods\Whatsit::offsetGet($offset) should either be compatible with ArrayAccess::offsetGet(mixed $offset): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/src/Pods/Whatsit.php on line 362

Deprecated: Return type of Pods\Whatsit::offsetSet($offset, $value) should either be compatible with ArrayAccess::offsetSet(mixed $offset, mixed $value): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/src/Pods/Whatsit.php on line 375

Deprecated: Return type of Pods\Whatsit::offsetUnset($offset) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/src/Pods/Whatsit.php on line 389

Deprecated: Return type of Pods\Whatsit::jsonSerialize() should either be compatible with JsonSerializable::jsonSerialize(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/src/Pods/Whatsit.php on line 285

Deprecated: Return type of Pods\Whatsit::current() should either be compatible with Iterator::current(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/src/Pods/Whatsit.php on line 306

Deprecated: Return type of Pods\Whatsit::next() should either be compatible with Iterator::next(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/src/Pods/Whatsit.php on line 322

Deprecated: Return type of Pods\Whatsit::key() should either be compatible with Iterator::key(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/src/Pods/Whatsit.php on line 315

Deprecated: Return type of Pods\Whatsit::valid() should either be compatible with Iterator::valid(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/src/Pods/Whatsit.php on line 329

Deprecated: Return type of Pods\Whatsit::rewind() should either be compatible with Iterator::rewind(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /www/thebottomlineh_300/public/wp-content/plugins/pods/src/Pods/Whatsit.php on line 299

Deprecated: DateTime::__construct(): Passing null to parameter #1 ($datetime) of type string is deprecated in /www/thebottomlineh_300/public/wp-includes/script-loader.php on line 333

Deprecated: strtolower(): Passing null to parameter #1 ($string) of type string is deprecated in /www/thebottomlineh_300/public/wp-includes/formatting.php on line 2145

Notice: register_post_type was called incorrectly. Post type names must be between 1 and 20 characters in length. Please see Debugging in WordPress for more information. (This message was added in version 4.2.0.) in /www/thebottomlineh_300/public/wp-includes/functions.php on line 5665

Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/thebottomlineh_300/public/wp-includes/class-wp.php on line 173

Deprecated: ltrim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/thebottomlineh_300/public/wp-includes/wp-db.php on line 3030

Warning: Cannot modify header information - headers already sent by (output started at /www/thebottomlineh_300/public/wp-includes/class-wp-block-list.php:14) in /www/thebottomlineh_300/public/wp-includes/feed-rss2.php on line 8
https://staging-thebottomlineh.kinsta.cloud A compendium of critical appraisals in Intensive Care Medicine research and related specialties Fri, 17 Dec 2021 11:54:47 +0000 en-GB hourly 1 https://wordpress.org/?v=5.8.15 https://staging-thebottomlineh.kinsta.cloud/wp-content/uploads/2016/05/cropped-tbl-favicon-2-32x32.png https://staging-thebottomlineh.kinsta.cloud 32 32 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/controling/?utm_source=rss&utm_medium=rss&utm_campaign=controling https://staging-thebottomlineh.kinsta.cloud/summaries/icm/controling/#respond Fri, 17 Dec 2021 11:54:47 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10194 Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study—a randomized clinical trial Bohé. Intensive Care Medicine 2021. https://doi.org/10.1007/s00134-021-06526-8 Clinical Question In critically unwell adults does targeting individualised glycaemic control compared to glycaemia < 180 mg/dL improve 90 day mortality? Background Hyperglycaemia has been shown to result in worse outcomes in the critically ill, especially in non-diabetic patients In […]]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/controling/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/combat-covid/?utm_source=rss&utm_medium=rss&utm_campaign=combat-covid https://staging-thebottomlineh.kinsta.cloud/summaries/combat-covid/#respond Fri, 10 Dec 2021 10:36:49 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10166 In mechanically ventilated patients with COVID-19 and severe endotheliopathy, does prostacylin compared with placebo, improve days alive without ventilation by day 28?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/combat-covid/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/coca/?utm_source=rss&utm_medium=rss&utm_campaign=coca https://staging-thebottomlineh.kinsta.cloud/summaries/coca/#respond Fri, 03 Dec 2021 16:20:28 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10160 In patients with out-of-hospital cardiac arrest, does calcium compared with placebo, improve sustained return of spontaneous circulation?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/coca/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/silence/?utm_source=rss&utm_medium=rss&utm_campaign=silence https://staging-thebottomlineh.kinsta.cloud/summaries/silence/#respond Wed, 17 Nov 2021 10:45:28 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9874 In patients near end of life, does subcutaneous scopolamine butylbromide compared with placebo, reduce the incidence of death rattle?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/silence/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/snocat/?utm_source=rss&utm_medium=rss&utm_campaign=snocat https://staging-thebottomlineh.kinsta.cloud/summaries/snocat/#respond Fri, 22 Oct 2021 13:31:38 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9594 Effect of Out-of-Hospital Sodium Nitrite on Survival to Hospital Admission After Cardiac Arrest: A Randomized Clinical Trial Kim @uwcardiology. JAMA. 2021 January 12;325(2):138-145. doi: 10.1001/jama.2020.24326. Clinical Question In patients with out-of-hospital cardiac arrest, does sodium nitrite, compared with placebo, improve survival to hospital admission? Background Out-of-hospital cardiac arrest continues to have a high risk of morbidity and mortality Nitrate therapy […]]]> https://staging-thebottomlineh.kinsta.cloud/summaries/snocat/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/vam-ihca/?utm_source=rss&utm_medium=rss&utm_campaign=vam-ihca https://staging-thebottomlineh.kinsta.cloud/summaries/icm/vam-ihca/#comments Fri, 15 Oct 2021 18:19:29 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=10090 Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial Anderson et al. JAMA 2021. doi:10.1001/jama.2021.16628 Clinical Question In adult patients suffering an in-hospital cardiac arrest (IHCA) does the use of vasopressin and methylprednisolone compared to a placebo result in increased rates of return of spontaneous circulation (ROSC)? […]]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/vam-ihca/feed/ 1 https://staging-thebottomlineh.kinsta.cloud/summaries/coast/?utm_source=rss&utm_medium=rss&utm_campaign=coast https://staging-thebottomlineh.kinsta.cloud/summaries/coast/#respond Fri, 08 Oct 2021 15:16:10 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9869 In hypoxic African children (oxygen saturations of between 80 and 91%) with pneumonia, does oxygen therapy reduce mortality when compared with a permissive hypoxia (no oxygen) strategy? In severely hypoxic children (oxygen saturations less than 80%), does high-flow nasal therapy reduce mortality when compared with low-flow oxygen therapy?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/coast/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/covert-mi/?utm_source=rss&utm_medium=rss&utm_campaign=covert-mi https://staging-thebottomlineh.kinsta.cloud/summaries/covert-mi/#respond Mon, 04 Oct 2021 19:56:41 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9944 In patients who present with an acute STEMI  and are referred for percutaneous coronary intervention (PCI), does colchicine in comparsion with placebo reduce myocardial injury?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/covert-mi/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/recovery-regen-cov/?utm_source=rss&utm_medium=rss&utm_campaign=recovery-regen-cov https://staging-thebottomlineh.kinsta.cloud/summaries/recovery-regen-cov/#respond Thu, 30 Sep 2021 21:29:01 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9857 Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial @PeterHorby. medRxiv pre-print 2021 doi: https://doi.org/10.1101/2021.06.15.21258542 Clinical Question In hospitalised patients with COVID-19, does the addition of monoclonal antibodies REGEN-COV (carsirivimab & imdevimab) to standard care, compared with standard care alone, improve 28 day mortality? Background Monoclonal antibodies have been shown to be […]]]> https://staging-thebottomlineh.kinsta.cloud/summaries/recovery-regen-cov/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/the-rest-trial/?utm_source=rss&utm_medium=rss&utm_campaign=the-rest-trial https://staging-thebottomlineh.kinsta.cloud/summaries/icm/the-rest-trial/#comments Mon, 13 Sep 2021 07:08:00 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9920 In mechanically ventilated patients with acute hypoxaemic respiratory failure, does lowering tidal volume using extracorporeal carbon dioxide removal, compared with conventional low tidal volume ventilation, improve day 90 all-cause mortality?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/the-rest-trial/feed/ 1 https://staging-thebottomlineh.kinsta.cloud/summaries/covid-steroid-2/?utm_source=rss&utm_medium=rss&utm_campaign=covid-steroid-2 https://staging-thebottomlineh.kinsta.cloud/summaries/covid-steroid-2/#respond Thu, 09 Sep 2021 09:38:49 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9836 In patients with severe COVID, does 12mg dexamethasone vs 6mg dexamethasone increase the number of days alive without life support at 28 days?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/covid-steroid-2/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/tomahawk/?utm_source=rss&utm_medium=rss&utm_campaign=tomahawk https://staging-thebottomlineh.kinsta.cloud/summaries/icm/tomahawk/#respond Sun, 05 Sep 2021 06:31:48 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9882 Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation Desch S et al. NEJM 2021. DOI: 10.1056/NEJMoa2101909 Clinical Question In adults > 30 years old suffering out-of-hospital cardiac arrest (OOHCA) without ST elevation on their ECG does routine immediate coronary angiography compared to a delayed or selective approach to coronary angiography improve 30-day all-cause mortality? Background The DISCO pilot study showed […]]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/tomahawk/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/recovery-rs/?utm_source=rss&utm_medium=rss&utm_campaign=recovery-rs https://staging-thebottomlineh.kinsta.cloud/summaries/icm/recovery-rs/#comments Sun, 22 Aug 2021 07:12:44 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9771 In hospitalised patients with COVID-19 requiring >40% FiO2 to achieve SaO2>94%, does the use of continuous positive airway pressure (CPAP) or high flow nasal oxygen (HFNO) compared with conventional O2 therapy (COT) reduce the incidence of tracheal intubation or death within 30 days?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/recovery-rs/feed/ 2 https://staging-thebottomlineh.kinsta.cloud/summaries/treatment-of-multisystem-inflammatory-syndrome-in-children/?utm_source=rss&utm_medium=rss&utm_campaign=treatment-of-multisystem-inflammatory-syndrome-in-children https://staging-thebottomlineh.kinsta.cloud/summaries/treatment-of-multisystem-inflammatory-syndrome-in-children/#respond Fri, 30 Jul 2021 12:24:43 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9617 Treatment of Multisystem Inflammatory Syndrome in Children McArdle. NEJM 2021; 385: 35-45.DOI: 10.1056/NEJMoa2102968 Clinical Question In children with multisystem inflammatory syndrome, what affect do different treatments have on the composite of inotropic support or mechanical ventilation by day 2 or death, and disease severity by day 2? Background Multisystem inflammatory syndrome in children (MIS-C) is a new, rare but serious […]]]> https://staging-thebottomlineh.kinsta.cloud/summaries/treatment-of-multisystem-inflammatory-syndrome-in-children/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/cobi/?utm_source=rss&utm_medium=rss&utm_campaign=cobi https://staging-thebottomlineh.kinsta.cloud/summaries/cobi/#comments Thu, 15 Jul 2021 09:30:27 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9659 In adult patients with moderate to severe traumatic brain injury, does a continuous infusion of 20% saline, compared with standard care along, improve neurological outcomes at six months?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/cobi/feed/ 1 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/ttm2/?utm_source=rss&utm_medium=rss&utm_campaign=ttm2 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/ttm2/#comments Thu, 17 Jun 2021 10:01:26 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9620 In patients who are unconscious following out-of-hospital cardiac arrest, does targeted hypothermia compared with targeted normothermia, impact all-cause mortality?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/ttm2/feed/ 2 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/styleto/?utm_source=rss&utm_medium=rss&utm_campaign=styleto https://staging-thebottomlineh.kinsta.cloud/summaries/icm/styleto/#respond Thu, 10 Jun 2021 08:59:57 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9598 In critically ill adults, does the use of an intubating stylet compared to tracheal tube alone, increase first-attempt successful intubation?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/styleto/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/pom/traap2/?utm_source=rss&utm_medium=rss&utm_campaign=traap2 https://staging-thebottomlineh.kinsta.cloud/summaries/pom/traap2/#respond Fri, 14 May 2021 22:55:04 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9568 In patients undergoing caesarean section (CS) does the administration of tranexamic acid (TXA) when compared to placebo result in a lower incidence of calculated estimated blood loss of red blood cell transfusion by day 2?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/pom/traap2/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/mends2/?utm_source=rss&utm_medium=rss&utm_campaign=mends2 https://staging-thebottomlineh.kinsta.cloud/summaries/mends2/#respond Fri, 07 May 2021 13:07:00 +0000 https://staging-thebottomlineh.kinsta.cloud/?p=9495 In mechanically ventilated adults with sepsis, does the use of dexmedetomidine, compared with propofol, for continuous sedation improve the number of days alive without delirium or coma?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/mends2/feed/ 0 https://staging-thebottomlineh.kinsta.cloud/summaries/icm/sjoblom/?utm_source=rss&utm_medium=rss&utm_campaign=sjoblom https://staging-thebottomlineh.kinsta.cloud/summaries/icm/sjoblom/#respond Thu, 29 Apr 2021 15:50:31 +0000 http://staging-thebottomlineh.kinsta.cloud/?p=9415 In adult patients undergoing rapid sequence intubation for emergency surgery, does pre-oxygenation with high-flow nasal oxygen, compared with standard face-mask oxygen, reduce the incidence of oxygen desaturation?]]> https://staging-thebottomlineh.kinsta.cloud/summaries/icm/sjoblom/feed/ 0