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https://staging-thebottomlineh.kinsta.cloud
A compendium of critical appraisals in Intensive Care Medicine research and related specialtiesFri, 19 Jun 2020 14:34:16 +0000en-GB
hourly
1 https://wordpress.org/?v=5.8.14https://staging-thebottomlineh.kinsta.cloud/wp-content/uploads/2016/05/cropped-tbl-favicon-2-32x32.pngStroke – The Bottom Line
https://staging-thebottomlineh.kinsta.cloud
3232DIRECT-MT
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/direct-mt/?utm_source=rss&utm_medium=rss&utm_campaign=direct-mt
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/direct-mt/#respondFri, 19 Jun 2020 14:34:16 +0000http://staging-thebottomlineh.kinsta.cloud/?p=8526In patients with acute anterior ischaemic stroke, is endovascular thrombectomy alone, compared with endovascular thrombectomy preceded by intravenous alteplase, noninferior with respect to modified Rankin score at 90 days?]]>https://staging-thebottomlineh.kinsta.cloud/summaries/icm/direct-mt/feed/0PAUSE
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/pause/?utm_source=rss&utm_medium=rss&utm_campaign=pause
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/pause/#respondFri, 13 Sep 2019 13:31:06 +0000http://staging-thebottomlineh.kinsta.cloud/?p=7820In patients with atrial fibrillation (AF) on direct oral anticoagulant (DOAC) medications, does a standard approach to therapy interruption and resumption in the perioperative period result in an acceptable risk for bleeding and thromboembolic events?]]>https://staging-thebottomlineh.kinsta.cloud/summaries/icm/pause/feed/0EXTEND
https://staging-thebottomlineh.kinsta.cloud/summaries/extend/?utm_source=rss&utm_medium=rss&utm_campaign=extend
https://staging-thebottomlineh.kinsta.cloud/summaries/extend/#respondFri, 31 May 2019 15:21:07 +0000http://staging-thebottomlineh.kinsta.cloud/?p=7370In patients with acute ischaemic stroke, with salvageable brain tissue, does alteplase compared with placebo, administered between 4.5 - 9 hours post stroke onset, improve functional outcome at 90 days?]]>https://staging-thebottomlineh.kinsta.cloud/summaries/extend/feed/0MAPAS
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/mapas/?utm_source=rss&utm_medium=rss&utm_campaign=mapas
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/mapas/#respondFri, 10 May 2019 23:10:19 +0000http://staging-thebottomlineh.kinsta.cloud/?p=7484Early Manipulation of Arterial Blood Pressure in Acute Ischemic Stroke(MAPAS):Results of a Randomized Controlled Trial Luiz Antonio Nasi. Neurocritical Care 2019; doi: https://doi.org/10.1007/s12028-018-0642-5 Clinical Question In adult patients presenting within 12 hours of an acute ischaemic stroke (AIS), which of three targeted and pre-specified systolic blood pressure (SBP) ranges results in an improved functional outcome at 90 days? Background Significant […]]]>https://staging-thebottomlineh.kinsta.cloud/summaries/icm/mapas/feed/0TICH-2
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/tich-2/?utm_source=rss&utm_medium=rss&utm_campaign=tich-2
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/tich-2/#respondFri, 08 Mar 2019 12:00:45 +0000http://staging-thebottomlineh.kinsta.cloud/?p=6583In adults with acute, spontaneous intra-cerebral haemorrhage (ICH), does the administration of tranexamic acid (TXA) compared to a placebo improve functional status at 90 days?]]>https://staging-thebottomlineh.kinsta.cloud/summaries/icm/tich-2/feed/0EXTEND IA TNK
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/extend-ia-tnk/?utm_source=rss&utm_medium=rss&utm_campaign=extend-ia-tnk
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/extend-ia-tnk/#respondFri, 08 Jun 2018 12:00:01 +0000http://staging-thebottomlineh.kinsta.cloud/?p=5830In patients with anterior circulation strokes undergoing endovascular thrombectomy, is IV thrombolysis within 4.5 hours of stroke onset with tenecteplase, non-inferior to alteplase, at establishing reperfusion?]]>https://staging-thebottomlineh.kinsta.cloud/summaries/icm/extend-ia-tnk/feed/0DAWN
https://staging-thebottomlineh.kinsta.cloud/summaries/dawn/?utm_source=rss&utm_medium=rss&utm_campaign=dawn
https://staging-thebottomlineh.kinsta.cloud/summaries/dawn/#respondFri, 11 May 2018 12:22:46 +0000http://staging-thebottomlineh.kinsta.cloud/?p=5892In patients who are 6-24 hours post acute stroke, and have a mismatch between clinical deficit and infarct, does thrombectomy plus standard medical care, compared to standard medical care alone, improve functional outcomes at 90 days?]]>https://staging-thebottomlineh.kinsta.cloud/summaries/dawn/feed/0DEFUSE 3
https://staging-thebottomlineh.kinsta.cloud/summaries/em/defuse-3/?utm_source=rss&utm_medium=rss&utm_campaign=defuse-3
https://staging-thebottomlineh.kinsta.cloud/summaries/em/defuse-3/#respondFri, 30 Mar 2018 17:59:39 +0000http://staging-thebottomlineh.kinsta.cloud/?p=5509In patients with proximal internal carotid (ICA) or middle cerebral artery (MCA) occlusion with likely salvageable ischaemic brain tissue, does thrombectomy, at 6-16 hours post ischaemic stroke, in addition to medical therapy, compared to medical therapy alone, improve functional outcome at 90 days?]]>https://staging-thebottomlineh.kinsta.cloud/summaries/em/defuse-3/feed/0POCUS: Moretti
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/pocus-moretti/?utm_source=rss&utm_medium=rss&utm_campaign=pocus-moretti
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/pocus-moretti/#respondTue, 15 Nov 2016 12:00:28 +0000http://staging-thebottomlineh.kinsta.cloud/?p=1465In mechanically ventilated patients with subarachnoid hemorrhage (SAH), does the distensibility of IVC on ultrasound, predict fluid responsiveness measured by thermodilution?]]>https://staging-thebottomlineh.kinsta.cloud/summaries/icm/pocus-moretti/feed/0Anderson
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/anderson/?utm_source=rss&utm_medium=rss&utm_campaign=anderson
https://staging-thebottomlineh.kinsta.cloud/summaries/icm/anderson/#commentsFri, 27 May 2016 15:57:19 +0000http://staging-thebottomlineh.kinsta.cloud/?p=1538In patients with acute ischaemic stroke, is low-dose thrombolysis therapy with intravenous alteplase non-inferior to standard-dose therapy with respect to death and disability at 90 days?]]>https://staging-thebottomlineh.kinsta.cloud/summaries/icm/anderson/feed/3